Gene therapy for prostate cancer

Mitchell S Steiner and Jeffrey R Gingrich Department of Urology, University of Tennessee, Memphis, Tennessee 38163 _________________________________________________________________________________________________ Correspondence: Mitchell S. Steiner, MD, Department of Urology, University of Tennessee Medical Center, 956 Court Avenue, Memphis, Tennessee 38163. Telephone: 901-448-1492; Fax: 901-448-4743; E-mail: [email protected] Abbreviations: GDEPT, gene directed enzyme prodrug treatment; 6 MPDR, 6-methyl-9 (2 deoxy-β-D erythro-pentofuranosyl) purine; Ad, adenovirus; CMV, cytomegalovirus; MMTV, mouse mammary tumor virus; HSV, herpes simplex virus; tk, thymidine kinase; GCV, ganciclovir; DT, diptheria toxin; EBRT, external beam radiation treatment; PSA, prostate-specific antigen; PSE, prostate specific enhancer; ARE, androgen responsive element; PB, probasin; MHC, major histocompatability complex; TIL; tumor infiltrating lymphocytes; CTL, cytotoxic T cells; IL, interleukin; GM-CSF, granulocyte maturation-colony stimulating factor; bFGF, basic fibroblast growth factor